~78% of patients have classical/aggressive mantle cell lymphoma ~78% of patients have classical/aggressive mantle cell lymphoma

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MCL develops from malignant B cells within the lymph node4-7

  • Originates in the mantle zone of lymphoid follicles5,7
  • MCL cells characteristically exhibit chromosomal translocation t(11;14) (q13;q32) and overexpression of cyclin D1 in addition to expression of the CD19 and CD20 antigens6,8,9
    • Cyclin D1 disrupts the cell cycle, which results in MCL oncogenesis6
lymph node where mantle cell lymphoma develops lymph node where mantle cell lymphoma develops
  1. Germinal center
  2. Mantle zone
  3. Marginal zone

Adapted from Swerdlow SH, et al. Blood. 2016;127(20):2375-2390 and Arruga F, et al. Front Oncol. 2018;8:550. doi:10.3389/fonc.2018.00550


MCL cells are often located in the peripheral blood, bone marrow, spleen, and gastrointestinal tract10

figure showing common locations of mantle cell lymphoma in the body including peripheral blood, bone marrow, spleen, and gastrointestinal tract. figure showing common locations of mantle cell lymphoma in the body including peripheral blood, bone marrow, spleen, and gastrointestinal tract.

Patient demographics11,12

  • Median age is 69
  • ~3x more common in males
  • Non-hispanic, white

Most patients present with generalized lymphadenopathy; additional signs and symptoms of MCL include13-17:

  • Unexplained weight loss
  • Drenching night sweats
  • Fever
  • Fatigue
  • Lymphocytosis
  • Pain
  • Hepatosplenomegaly
  • GI symptoms
  • Skin rash

Pathological tests used for MCL diagnosis and risk assessment18

IHC stains and flow cytometry

IHC stains and flow cytometry

  • Cyclin D1
  • Ki-67 proliferation index
  • CD19
  • CD20
  • CD5
  • CD23
Genetic testing/chromosomal evaluation

Genetic testing/chromosomal evaluation

  • TP53
  • IGHV status
  • FISH test for t(11;14)(q13;q32)
Diagnostic testing

Diagnostic testing

  • PET and CT scans
  • Bone marrow biopsy
  • CBC, blood chemistry, and LDH
colonoscopy and upper GI endoscopy

Other testing

  • Colonoscopy
  • Upper GI endoscopy

MCL characteristics associated with high-risk for aggressive disease7,19

  • Presence of the TP53 mutation
  • Ki-67 index ≥30%
  • Blastoid/pleomorphic MCL
  • Complex karyotype
  • Presence of B symptoms
  • Elevated LDH
  • High-risk MIPI score

MCL progression within 2 years of diagnosis or treatment failure may identify a high-risk population20,21

CBC=complete blood count; CT=computed tomography; FISH=fluorescence in situ hybridization; IGHV=immunoglobulin heavy chain variable; IHC=immunohistochemistry; LDH=lactate dehydrogenase; MCL=mantle cell lymphoma; MIPI=Mantle Cell Lymphoma International Prognostic Index; PET, positron emission tomography.

References: 1. Cheminant M, Hermine O. Frontline therapy in mantle cell lymphoma: new standards in 2017. Am J Hematol Oncol. 2017;13(8):4-10. 2. Kumar A, Sha F, Toure A, et al. Patterns of survival in patients with recurrent mantle cell lymphoma in the modern era: progressive shortening in response duration and survival after each relapse. Blood Cancer J. 2019;9(50):1-10. 3. Jain P, Wang M. Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management. Am J Hematol. 2019;946:710-725. 4. Arruga F, Vaisitti T, Deaglio S. The NOTCH pathway and its mutations in mature B cell malignancies. Front Oncol. 2018;8:550. doi:10.3389/fonc.2018.00550. 5. Weisenburger DD, Kim H, Rappaport H. Mantle-zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma. Cancer. 1982;49(7):1429-1438. 6. Pileri SA, Falini B. Mantle cell lymphoma. Haematologica. 2009;94(11):1488-1492. 7. Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375-2390. 8. Aguilera NS, Bijwaard KE, Duncan B, et al. Differential expression of cyclin D1 in mantle cell lymphoma and other non-Hodgkin’s lymphomas. Am J Pathol. 1998;153(6):1969-1976. 9. Dreyling M, on behalf of the European MCL Network. Mantle cell lymphoma: biology, clinical presentation, and therapeutic approaches. Am Soc Clin Oncol Educ Book. 2014;34:191-198. 10. Veloza L, Ribera-Cortada I, Campo E. Mantle cell lymphoma pathology update in the 2016 WHO classification. Ann Lymphoma. 2019;3(3):1-17. 11. Fu S, Wang M, Lairson DR, Li R, Zhao B, and Du XL. Trends and variations in mantle cell lymphoma incidence from 1995 to 2013: A comparative study between Texas and National SEER areas. Oncotarget. 2017;8(68):112516-112529. 12. Fu S, Wang M, Li R, Lairson DR, Zhao B, and Du XL. Increase in survival for patients with mantle cell lymphoma in the era of novel agents in 1995–2013: findings from Texas and national SEER areas. Cancer Epidemiol. 2019;58:89-97. 13. Carvajal-Cuenca A, Sua LF, Silva NM, et al. In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior. Haematologica. 2012;97(2):270-278. 14. Inamdar AA, Goy A, Ayoub NM, et al. Mantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agents. Oncotarget. 2016;7(30):48692-48731. 15. National Cancer Institute. Mantle cell lymphoma. National Cancer Institute surveillance, epidemiology, and end results program website. https://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd5357/. Accessed June 25, 2020. 16. Wang Y, Ma S. Risk factors for etiology and prognosis of mantle cell lymphoma. Expert Rev Hematol. 2014;7(2):233-243. 17. Romaguera JE, Medeiros LJ, Hagemeister FB, et al. Frequency of gastrointestinal involvement and its clinical significance in mantle cell lymphoma. Cancer. 2003;97(3):586-591. 18. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for B-Cell Lymphomas V1.2020. © National Comprehensive Cancer Network, Inc. 2020. All rights reserved. Accessed June 25, 2020. To view the most recent and complete version of the guideline, go online to NCCN.org. 19. Cohen JB, Zain JM, Kahl BS. Current approaches to mantle cell lymphoma: diagnosis, prognosis, and therapies. Am Soc Clin Oncol Educ Book. 2017;37:512-525. 20. Visco C, Tisi MC, Evangelista A, et al. Time to progression of mantle cell lymphoma after high-dose cytarabine-based regimens defines patients risk for death. Br J Haematol. 2019;185(5):940-944. 21. Bond DA, Switchenko JM, Maddocks KJ, et al. Outcomes following early relapse in patients with mantle cell lymphoma. Blood. 2019;134(suppl 1):753.